Modulation in DNA Repair Mechanisms in non–small cell lung cancers

MSc student: Dina-Aina Zukic

This project is about exploring the possibilities of differential DNA repair mechanisms induced by selected compounds in healthy vs. cancer lung cells. The aim of the project is to prevent the induction of DNA lesions in healthy cells or to activate the DNA repair mechanisms. We are working currently on two lung cancer cell lines that have a certain mutation and a healthy cell line. With the help of many functional tests, we will be able to prove or disapprove our set aim of the master project. This will show us which drugs are cytoprotective and which are cytotoxic after the patient is being treated with the most common chemotherapy, Cisplatin, used in non – small cell lung cancer treatment. The outcome of this project will help know whether patients to use certain drugs while they are being treated with chemotherapy.